Brainsafe II (EU FP7)

IntraCranial Pressure (ICP) is the pressure of the intracranial cerebrospinal fluid inside the skull, it is affected onto the brain tissue and the cerebral blood circulation. ICP value is dynamic and ranges from 7 to 15 mm Hg in the normal range. An increase in intracranial pressure is a dangerous phenomenon that can occur as a result of intracranial hemorrhage, usually due to severe brain injury or stroke.

Today’s common intracranial pressure measurement methods are either performing lumbar puncture and spinal fluid extraction, or by drilling inside the patient's skull and inserting a pressure monitoring sensor into the measurement area within the brain. These interventions are risky and complex. In addition, both invasive methods may also aggravate the phenomenon, increase the pressure and introduce dangerous infections to the body.

In recent years, an innovative approach has been developed for non-invasive measurement of absolute intracranial pressure based on measuring the blood flow variability in two different segments of the ophthalmic artery using a dual-depth ultrasonic transducer, while applying external pressure that overcomes the blood flow to the eyeball. The method does not require specific calibration per patient as it is automatically self-calibrated to the patient’s blood pressure.